Older adults with LDL cholesterol levels above 130 mg/dL live longer than older adults with LDL cholesterol levels below 130 mg/dL. 

The participants of the study were from Sardinia, Italy (image: businessinsider.com). 

Metabolism

Model: 10-month-old and 22-month-old naturally aged mice / Rats with Partial Discectomy (PDE)-induced Temporomandibular Joint Osteoarthritis (TMJOA).
Dosage: 0.25% αKG and  0.75% αKG
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Longevity Compound Thwarts Age-Related Joint Degeneration

Researchers found that alpha-ketoglutarate (αKG) can treat osteoarthritis by preserving cartilage and reducing joint inflammation. 

Skin &amp; Muscle

Model: 3-month-old LDLR−/− pigs
Dosage: 400 nM of SWNT or SWNT-SHP1i 
was infused intravenously for ~15–30 min, once a week, for 12 weeks

“Trojan Horse” Nanoparticles: A Breakthrough in Treatment for Atherosclerosis 

Stanford School of Medicine researchers develop safe nanoparticles that target dying cells in atherosclerotic plaque and reduce vascular inflammation.

Cardiovascular

Model: 5xFAD mice
Dosage: 5-µL sprayed into each nostril at concentrations of 30 × 109/100 µL once weekly for two weeks

Exploring a Nasal Spray that Might Delay Alzheimer’s Progression by Years

Researchers use nano-sized vesicles derived from neural stem cells to preserve cognition as well as reduce brain inflammation and plaque buildup in an Alzheimer’s mouse model.

(An aged woman using an intranasal spray to avert Alzheimer's disease progression | NAD.com)

Brain &amp; Neurons

Studies suggest that supplementation with melatonin may slow brain aging, thereby improving cognition. 

Search Result: plaque

New Study Shows People with Higher Cholesterol Live Longer than People with Lower Cholesterol

Longevity Compound Thwarts Age-Related Joint Degeneration

“Trojan Horse” Nanoparticles: A Breakthrough in Treatment for Atherosclerosis

Exploring a Nasal Spray that Might Delay Alzheimer’s Progression by Years

Does Melatonin Improve Cognition? What the Latest Research Says